Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT

• Status: Unknown status
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Study if supporting luteal phase of high responder (high egg production or high Estradiol level) long Gn_Rh agonist protocol ICSI/IVF cycle by combined Estradiol and progesterone impairs or improves outcome in terms of pregnancy and implanation rates.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura Integrated Fertility Center
• Treatments: Estradiol; Progesterone; Triptorelin Pamoate

Criteria

Inclusion criteria

• age<40 years,

• first ICSI cycle,

• third day FSH< 10 mIU/mL,

• serum E2 level on day of hCG administration <4,000 pg/mL,

• number of ova obtained >15

Exclusion Criteria:

• age 40 years or more,

• basal FSH 10 mIU/mL or more ,

• eggs retrieved 15 or less ,

• E2 level on day of hCG administration 4000 or more pg/ mL or more,

• repeat ICSI , need for PGD, presence of myoma , hydrosalpinx (unless disconnected)