Iron Treatment of Sleep Disorders in Children With Autism Spectrum Disorder
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
Autism Spectrum Disorders (ASD) are characterized by difficulties in language, social
communication, and repetitive and restricted behaviors. ASD affects as many as 1 in 90-150
children. Sleep issues/insomnia is very common in children with ASD (50-80%). Insomnia has a
negative impact on both the developmental and behavioral function of the child and the
quality of life for the family. Causes of insomnia in children with ASD are multifactorial
and can be difficult to treat effectively. Low iron stores, as manifest by low serum ferritin
levels, is also common in children with ASD. Both insomnia and low iron stores are associated
with Restless Legs Syndrome (RLS) and Periodic Limb Movement of Sleep (PLMS). Children with
ASD often have difficulty communicating symptoms or tolerating Polysomnography (Sleep Study).
This makes establishing a diagnosis of RLS or PLMS very difficult in children with ASD.
Phase:
Phase 2
Details
Lead Sponsor:
University of Colorado, Denver
Collaborators:
Autism Treatment Network Health Resources and Services Administration (HRSA) Massachusetts General Hospital The Emmes Company, LLC The EMMES Corporation