This study involved human volunteers undertaking a high-altitude expedition. It assessed
changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
Participants included a subgroup of those taking part in an existing adventurous training
expedition and were randomised in a 1:1 fashion to receive either intravenous iron or normal
saline several weeks prior to departure. During the expedition, participants were
investigated by means of transthoracic echocardiography, peripheral oxygen saturation
measurement and heart rate monitoring and through the drawing of venous blood samples. Bloods
were later analysed for markers of iron status.