Iron is an essential micronutrient that plays an important role in cellular functions of all
microorganisms. Both iron deficiency and iron excess during the early weeks of life can have
severe effects on neurodevelopment that may persist into adulthood and may not be corrected
by restoration of normal iron levels.
Iron overload remains a significant concern in preterm infants because they have low levels
of iron-binding proteins and immature antioxidant systems.
The aim of the study is to evaluate if iron supplementation is required/necessary in VLBW
Very Low Birth Weight (less than 1500 grams) and to assess the efficacy and safety of the
iron supplementation practice for VLBW preterm infants as implemented in the Neonatal
Intensive Care Unit (NICU) at the Ha'Emek Medical Center, Afula, Israel.