This is a trial with an observational and an interventional arm, in patients with moderate to
severe anemia and control subjects. The main purposes of this study is to phenotype the scope
of neurocognitive deficits from iron deficiency anemia (IDA) in adult women, determine
derangements in cerebral perfusion, vascular reactivity, functional connectivity, and blood
brain barrier permeability in adult-onset IDA and relate them to neurocognitive deficits, as
well as determine the reversibility and durability of both the physiologic and neurocognitive
derangements by iron replacement therapy. All eligible subjects will be asked to provide
informed consent before participating in the study.