Irinotecan and Celecoxib in Treating Patients With Unresectable or Metastatic Colorectal Cancer
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as irinotecan, work in different ways to stop
tumor cells from dividing so they stop growing or die. Celecoxib may stop the growth of tumor
cells by blocking the enzymes necessary for their growth. Giving irinotecan with celecoxib
may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when
given with celecoxib in treating patients with unresectable or metastatic colorectal cancer.