Investigation of the Strategy of Preventing Post-operative Opioid-induced Hyperalgesia
Status:
Unknown status
Trial end date:
2019-12-31
Target enrollment:
Participant gender:
Summary
The concept of Enhanced Recovery After Surgery(ERAS) has been prevalent in recent years. In
the ERAS guideline, short-acting anesthetics, instead of long-acting opioid anesthetics, were
recommended during surgery to decrease post-operative complication and length of hospital
stay. Propofol-remifentanil based total intravenous anesthesia (TIVA) can provide quicker
emergence and decreased post-operative nausea and vomiting. However, the prescription of
opioid (especially remifentanil) may induce opioid-induced hyperalgesia (OIH) and increase
the requirement of analgesics. Previous studies provided some strategies to prevent OIH. The
purpose of this study is to investigate the effect of adding remifentanil(1 mcg/kg) after
emergence and endotracheal extubation in breast cancer females receiving breast surgery under
propofol-remifentanil based TIVA for the prevention of OIH.