Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans
Status:
Completed
Trial end date:
2019-03-29
Target enrollment:
Participant gender:
Summary
We propose to study both stool and urine energy loss in 24 individuals on two experimental
diets (50% increased and 50% reduced nutrient load relative to body size) in a random
cross-over design. Following this over/underfeeding, volunteers will also be randomly
assigned to a placebo versus oral antibiotic medication arm. This study will extend our
previous findings by investigating whether 1) nutrient absorption changes upon similar
increases/decreases in relative nutrient load and 2) whether manipulation of gut microbial
communities with antibiotics alters nutrient absorption and 3) how these changes may affect
glucose tolerance and fat storage.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)