Overview

Investigation of the Effect of Upper Gastrointestinal Disease on the Pharmacokinetics of Oral Semaglutide in Subjects With Type 2 Diabetes.

Status:
Completed
Trial end date:
2017-11-24
Target enrollment:
0
Participant gender:
All
Summary
This trial is conducted in Europe. The aim of this trial is, to investigate the effect of upper gastrointestinal disease on the pharmacokinetics (the exposure of the trial drug in the body) of oral semaglutide in subjects with type 2 diabetes.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Novo Nordisk A/S
Criteria
Inclusion Criteria:

- Male or female, aged 18-80 years (both inclusive) at the time of signing informed
consent

- Body mass index (BMI) between 18.5-39.9 kg/m^2 (both inclusive)

- Subjects diagnosed clinically with type 2 diabetes mellitus for at least 180 days
prior to the first screening visit

- For subjects with upper gastrointestinal (GI) disease: Diagnosed with chronic
gastritis and/or gastroesophageal reflux disease (GERD) at screening

Exclusion Criteria:

- Female who is pregnant, breast-feeding or intends to become pregnant or is of
child-bearing potential and not using a highly effective contraceptive method
(adequate contraceptive measures as required by local regulation or practice). (Highly
effective contraceptive methods are considered those with a failure rate less than 1%
undesired pregnancies per year including surgical sterilisation, hormonal intrauterine
devices (coil), oral hormonal contraceptives, sexual abstinence or a surgically
sterilised partner)

- History of pancreatitis (acute or chronic)

- History of major surgical procedures involving the stomach potentially affecting
absorption of trial product (e.g. subtotal and total gastrectomy, sleeve gastrectomy,
gastric bypass surgery)

- Unable or unwilling to refrain from smoking during the in-patient periods

- Any blood draw in excess of 50 mL in the past 30 days, or donation of blood or plasma
in excess of 400 mL within 90 days of the first screening visit