Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women
Status:
Recruiting
Trial end date:
2025-10-16
Target enrollment:
Participant gender:
Summary
There is significant evidence outlining the importance of inflammation in the pathogenesis of
coronary artery disease. Important differences exist between sexes in incidence, disease
patterns and outcomes in coronary artery disease that is not well understood. It is likely
that key differences in the underlying biological mechanism, in particular in inflammatory
responses, play a part in underpinning these differences. Previous evidence demonstrates that
healthy females appear to be more adept at resolving inflammation compared to healthy males.
Since inflammation is thought to be a key initiating phenomenon in coronary artery disease
the investigators will examine the differences in inflammatory resolution between the sexes
in healthy volunteers.