Overview

Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI

Status:
Unknown status
Trial end date:
2018-06-01
Target enrollment:
0
Participant gender:
Female
Summary
The investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging (BBI) MRI.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Danish Headache Center
Treatments:
Cilostazol
Ferrosoferric Oxide
Sumatriptan
Criteria
Inclusion Criteria:

- Written informed consent

- Subject has migraine without aura according to criteria of the International Headache
Society (IHS)

- Subject has unilateral migraine 70% of the time

- Migraine can be pharmacologically provoked in the subject using cilostazol.

- Subject is on birth control

- Subject has no other medical history

Exclusion Criteria:

- Subject suffers from bilateral migraine

- Subject suffers from migraine with aura

- Subject suffers from other primary headaches as specified by IHS criteria

- Pregnant or breast feeding subjects

- Subjects with contraindications for undergoing MRI scans

- Any known drug allergy

- Any signs or disorders of iron overload, including but not limited to hemosiderosis
and porphyria cutanea tarda