Investigation of Lung Ventilation Inhomogeneity in Pediatric Asthma

• Status: Completed
• Trial end date: 2018-05-23
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study is to determine if well-controlled asthmatic patients followed in subspecialty asthma clinics between the ages of 3 - 18 years can be distinguished from healthy controls using lung clearance index, a parameter from the multiple breath washout test. Also, to correlate lung clearance index with asthma sputum cell counts.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: The Hospital for Sick Children
• Treatments: Bronchodilator Agents

Criteria

Inclusion Criteria:

• Asthma Subjects:

• 3 - 18 years of age at enrolment

• Clinically stable at enrolment

• Physician diagnosis of asthma and attending follow-up in the Asthma Clinic

Exclusion Criteria:

• Asthma Subjects:

• Born premature (before 37 weeks gestational age)

• Low birth weight (less than 2.5 kilograms)

• History of congenital heart disease, neuromuscular disorder or bone disease

• History of any chronic lung disease other than asthma

• Respiratory infection in last three weeks

• Change in medication in last three weeks (including oral steroids)

• Current or previous history of smoking