Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
Status:
Withdrawn
Trial end date:
2012-06-01
Target enrollment:
Participant gender:
Summary
In this study the gender specificity of the effects of furosemide in female and male
volunteers will be investigated. The main objective is gender-specific comparison of the
pharmacokinetic parameters of furosemide in relation to the effect of furosemide (urinary
excretion). Secondary objectives are the gender-specific comparison of renal and systemic PAH
clearance with the clearance of furosemide and the influence of various genetic polymorphisms
on the variability of furosemide pharmacokinetics.