Investigation of Antipsoriatic Effects of UVB-induced Synthesis of 1alpha, 25-Dihydroxyvitamin D3 (1alpha, 25(OH)2D3, Calcitriol)in Keratinocytes of Psoriatic Skin, Using Cytochrom-P(CYP)Inhibitor Ketokonazol

• Status: Unknown status
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Exploration of antipsoriatic effects of UVB-therapy +/- CYP-inhibitor Ketokonazol on affected psoriatic skin

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität Dresden
• Treatments: Calcitriol; Dihydroxycholecalciferols; Ketoconazole

Criteria

Inclusion Criteria:

• age: 18- 80

• diagnosis of psoriasis vulgaris (mild- middle)

• no other current antipsoriatic therapy (systemic/topical)

• at least 5 psoriatic areas of 5x5 cm

Exclusion Criteria:

• pregnancy/nursing mothers

• women in reproductive age without adequate contraception

• severe and acute forms of psoriasis vulgaris

• patients receiving systemic or topical antipsoroatic treatment in past 3 month

• UV-therapy in past 3 month

• patients having a positive anamnesis for squamous cell carcinoma, malignant melanoma, basalioma

• epilepsy