Investigating the Safety of LEO 158968 in Healthy Volunteers
Status:
Not yet recruiting
Trial end date:
2024-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate what side effects the new compound LEO 158968
might cause and how well it is tolerated when it is used by healthy participants. It will
also investigate how quickly and to what extent LEO 158968 is distributed and eliminated from
the body and if LEO 158968 causes the body to make antibodies.
In the single ascending dose (SAD) cohorts, participants will receive escalating doses of LEO
158968 if the safety and tolerability results of the initial participants up to 48 hours (or
4 days for SC dosing) following dosing are acceptable to the Investigator.
In the multiple ascending dose (MAD) cohorts, the dose of LEO 158968 will be determined based
on results derived from the earlier SAD cohorts and additional preclinical data from a 5-week
good laboratory practice (GLP) cynomolgus monkey toxicology study.