Investigating the Novel Observation of Right-left Difference in Uterine Artery Vascular Resistance in Pre-eclampsia
Status:
Withdrawn
Trial end date:
2009-10-01
Target enrollment:
Participant gender:
Summary
The investigators previously demonstrated that epidural ropivacaine reduces uterine artery
vascular resistance in a dose dependent manner in pre-eclampsia. The investigators also noted
a marked right-left difference in vascular resistance between paired uterine arteries, which
was almost completely abolished following epidural ropivacaine. However, this novel
observation was not a stated outcome variable before the study began. This study assesses
right-left difference in vascular resistance between paired uterine arteries as a primary
end-point, assesses the dose-response effect of epidural lidocaine and compares the effect
observed in pre-eclampsia with that in two control populations (term normal pregnancy and
non-pregnant controls).