Investigating the Effects of Nabilone on Endocannabinoid Metabolism
Status:
Not yet recruiting
Trial end date:
2026-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to learn about the effects of a cannabis-like substance,
nabilone, on the levels of endocannabinoid enzyme fatty acid amide hydrolase (FAAH) in brain
of healthy individuals. Using magnetic resonance imagine (MRI) and positron emission
tomography (PET), the main questions we aim to answer are: 1) Does nabilone decrease levels
of FAAH in the brain? and 2) Are changes in levels of FAAH associated with clinical response
to nabilone? Participants will complete:
- An in-person interview (~4 hours)
- Two brain imaging scanning sessions (~11 hours)
- A one week 2 mg titrated dose of nabilone
- Virtual check-ins (up to ~1.5 hours)