Investigating the Biological Effects of the Addition of Zoledronic Acid to Pre-operative Chemotherapy in Breast Cancer
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
There is clear preclinical in vitro and in vivo evidence of sequence dependent synergy
between chemotherapy agents and zoledronic acid. The aim of the study is to investigate if
the synergistic increase in tumour cell apoptosis observed in preclinical studies occurs in
patients. The hypothesis for this study is that there may be anti-tumour benefits of the
sequential application of chemotherapy agents followed by zoledronic acid in patients with
invasive breast cancer.