Investigating the Anti-Human Immunodeficiency Virus (HIV) & Anti-inflammatory Effect of Chloroquine
Status:
Terminated
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Summary: Chloroquine is a medication that in laboratory settings has significant anti-HIV
effects in HIV infected T-cells. Chloroquine has been used safely for over 60 years for
malaria treatment and prevention, and it also has significant anti-inflammatory effects. No
formal study of chloroquine has been performed in people with HIV infection. Chloroquine is
used worldwide and is quite inexpensive outside of the United States. If shown to be
effective, chloroquine could be a very important tool worldwide in delaying HIV disease
progression which would extend the time period without needing anti-retroviral therapy. In
countries where anti-retroviral therapy is not available, this could be very helpful.
This is an 8 week trial study requiring 3 study visits. Participants will be ask to take a
once a day study medication (chloroquine or placebo) for 8 weeks and have three blood draws
for CD4 counts, HIV viral loads, and other research tests. The visits are at study
enrollment, 4 weeks, and 8 weeks.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute