Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
Status:
Recruiting
Trial end date:
2024-09-30
Target enrollment:
Participant gender:
Summary
The goal of this study is to understand the role of brain glucose transport in individuals
with obesity and the association with cerebral hypometabolism and these individuals' response
to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose
transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS).
The secondary premises are that this reduction is driven by elevated non esterified fatty
acids which act to turn on specific signaling pathways that regulate brain GLUT1 levels.