This study assesses the intervention with antifibrotic agents, specifically interferon (IFN)
to reduce the magnitude and duration of hypertrophic scar. Burn patients with hypertrophic
scar are randomly assigned to either an intervention IFN group or a placebo control group by
subcutaneous injection three times a week. Patients are assessed using cutometer, mexameter,
standardized photography, urinalysis, blood work, tissue biopsies and the Vancouver Burn Scar
Assessment (VBSA) which rates selected HTS based on color, vascularity, height, pliability,
itchiness and pain sensitivity. Once on treatment patients are assessed monthly for the six
month treatment period.