Intravenous and Perineural Dexamethasone for Brachial Plexus Block in Hand Surgery

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate the if the administration of dexamethasone both around the nerve and in the vein (perineural and intravenous (IV)) will prolong the duration of pain relief from ropivacaine when compared with ropivacaine local block alone or when administered along with IV dexamethasone in patients undergoing hand surgery.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ohio State University
• Treatments: BB 1101; Dexamethasone; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Adult male and female patients age 18-80

• Undergoing distal radius ORIF (open reduction internal fixation) or CMC (Carpometacarpal) arthroplasty

• ASA (American Society of Anesthesiologists) I, II,III

• Patients who provide a signed written informed consent

• Have a valid phone number and be able to speak, read, and write in English

Exclusion Criteria:

• Any documented cognitive or psychological disorders that, in the opinion of the principal investigator, can interfere with the patients' pain perception

• Diabetes Mellitus

• Vulnerable populations: pregnant females, prisoners, breast feeding

• Contraindication to nerve block: local infections, bleeding disorders, shoulder deformity, allergy to local anesthetic or dexamethasone

• Severe lung disease, known contralateral phrenic nerve injury

• Previous history of chronic pain diseases requiring consistent analgesic therapy for at least 1 month prior to surgery

• Presence of any medical condition that, in the opinion of the principal investigator, should exclude the patient from the study

• BMI ≥ 40 kg/m2