Intravenous and Intraperitoneal Lignocaine for Perioperative Analgesia in Laparoscopic Colon Resections

• Status: Completed
• Trial end date: 2019-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate the analgesic effects of intraperitoneal lignocaine (IPL) compared with intravenous lignocaine (IVL) after laparoscopic colon resections. We plan to run a 2 group randomized, double blind, clinical trial which will look into morphine consumption as the primary outcome.

Group 1 (IV lignocaine)- IV bolus of lignocaine and a 3 day post operative IV lignocaine infusion. Intra peritoneal (IP) bolus of normal saline + 3 day post operative IP normal saline infusion

Group 2 (IP lignocaine)- IV bolus of normal saline and a 3 day post operative IV normal saline infusion. IP bolus of lignocaine + 3 day post operative IP lignocaine infusion

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Auckland, New Zealand
• Treatments: Lidocaine

Criteria

Inclusion Criteria:

• consecutive consenting patients undergoing elective laparoscopic colonic resections will be recruited from surgical outpatient clinics at Manukau Super Clinic.

Exclusion Criteria:

• under 16 years of age

• acute colonic resection

• those with ASA >= 4

• previous adverse reaction/allergy to local anaesthetic,

• surgery for rectal lesions which was defined as lesion within 15 cm of the anal verge

• preoperative systemic steroid dependence

• hepatic dysfunction, opioid use greater than 6 months

• a diagnosis of Chronic Pain Syndrome

• inability to consent or complete data scores in the study questionnaires due to cognitive impairment and/or language barrier.