Overview

Intravenous Paracetamol or Morphine for the Treatment of Acute Flank Pain

Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
0
Participant gender:
All
Summary
STUDY OBJECTIVE: This randomized, controlled trial evaluates the analgesic efficacy and safety of intravenous single-dose paracetamol and morphine for the treatment of acute flank pain. METHODS: The investigators conducted a randomized, double-blind, controlled clinical trial comparing single intravenous doses of paracetamol (1 g) and morphine (0.1 mg/kg) for patients presenting to the emergency department (ED) with acute flank pain. Subjects with inadequate pain relief at 30 minutes received rescue fentanyl (0.75 microg/kg).
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Pamukkale University
Treatments:
Acetaminophen
Morphine
Criteria
Inclusion Criteria:

Adults (aged 16 to 55 years old) with acute low back pain were eligible for inclusion in
the study

Exclusion Criteria:

- known allergy or contraindication to morphine, paracetamol, or any opioid analgesic

- hemodynamic instability; fever (temperature > 38°C [100.4°F])

- evidence of peritoneal inflammation

- documented or suspected pregnancy

- known or suspected aortic dissection or aneurysm

- use of any analgesic within 6 hours of ED presentation

- previous study enrollment Patients with known renal, pulmonary, cardiac, or hepatic
failure, as well as those with renal transplantation, were also excluded.