Intravenous Paracetamol for Postoperative Pain

• Status: Completed
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to define if intravenous paracetamol may improve analgesia and outcome in pediatric surgical patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) postoperatively.

Hypothesis: intravenous paracetamol in a dose 60 mg/kg/24 h IV, given in addition to IV ketoprofen (4,5 mg/kg/24h), improves analgesia and physical recovery in children and adolescents following surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lithuanian University of Health Sciences
• Treatments: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Ketoprofen; Morphine; Pharmaceutical Solutions; Tramadol

Criteria

Inclusion Criteria:

• Patients 1-18 years of age, undergoing general, plastic or orthopedic surgery with expected median to severe pain postoperatively.

• physical status of the patient corresponding to American Society of Anesthesiologists (ASA) class 1 or 2

• Signed written informed consent by parents/official caregivers.

Exclusion Criteria:

• Allergy to paracetamol, ketoprofen, tramadol, morphine or any NSAID

• oncologic disease

• central nervous system disease

• renal dysfunction

• hepatic dysfunction

• bronchial asthma

• ulcer(s) in gastrointestinal system

• hemorrhagic diathesis

• chronic use of NSAIDs

• chronic use of opioids

• chronic use of anticoagulants

• female patient is known to be pregnant