Intravenous Oxytocin Versus Tranexamic Acid in Reducing Blood Loss During Abdominal Myomectomy.

• Status: Completed
• Trial end date: 2020-03-15
• Target enrollment: 0
• Participant gender: Female

Summary

Uterine leiomyomas (fibroids) are the most common benign tumors among women. Fibroids are found in approximately 20% of women over 35 years of age. In 20-50% of patients, fibroids may cause problems such as heavy menstrual bleeding, anemia, pelvic pain, pressure symptoms from extrinsic compression of the colorectal and urinary tract. Surgery is indicated for symptomatic uterine leiomyomas; hysterectomy for women who have completed childbearing (women > 40 years old), and myomectomy for women <40 years old who wish to preserve uterus and fertility.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Oxytocin; Tranexamic Acid

Criteria

Inclusion Criteria:

• • Age group (18-50) years old

• Intramural or interstitial myomas (more than 5 cm)

• Symptomatic myomas (heavy menstrual bleeding or pain during menstruation)

• Abdominal myomectomy

• No medical disorders

• No coagulation disorders

Exclusion Criteria:

• • Age group (less than 18 yrs old)

• Age group (more than 50 yrs old)

• Subserous or submucous myomas

• Laparoscopic or hysteroscopic myomectomy

• Medical disorders (for example uncontrolled hypertension, diabetes mellitus, renal or hepatic disorders)

• Coagulation disorders

• Previous use of anticoagulant drugs

• Previous myomectomy

• Allergy to Tranexamic acid or oxytocin

• Malignant features by U/S or examination

• Pregnancy

• Previous hormonal therapy (GnRH analogues)