Intravenous Milk Thistle (Silibinin-Legalon) for Hepatic Failure Induced by Amatoxin/Amanita Mushroom Poisoning
Status:
Terminated
Trial end date:
2019-09-18
Target enrollment:
Participant gender:
Summary
Legalon® SIL will be administered to patients with amatoxin poisoning diagnosed by history,
gastrointestinal symptoms, elevated liver enzymes, and/or diagnostic assay (should one become
available). Patients may or may not also demonstrate abnormalities in bilirubin and/or
creatinine. Treatment consists of a 5 mg/kg loading dose followed by 20 mg/kg/day via
continuous infusion. The treating physician is expected to administer supportive therapy of
his/her choosing but consistent with best practices. Legalon® SIL will be stopped when
coagulopathy is no longer present, and when liver function tests have returned significantly
towards the normal range. Patients will be followed 7-14 days after the end of Legalon® SIL
therapy with follow up lab studies.