Intravenous Metoclopramide in the Acute Treatment of Migraine: A Double-blind, Randomized, Placebo-controlled Trial
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Migraine attacks were frequently diagnosed in the emergency departments. Also intravenous
metoclopramide was a commonly used drug in the acute abortive treatment of migraine. However,
the role of metoclopramide was based on three randomized, placebo-controlled studies, which
were carried out with relatively few patients. Those trials suggested that metoclopramide
produced larger improvements in visual analog scale (VAS) scores, however they revealed
conflicting results and had significant methodological problems (risk of bias, allocation of
concealment, intention-to-treat analysis). The investigators aimed to analyse the effects of
intravenous metoclopramide in acute migraine attacks comparing with placebo.