Intravenous Lidocaine and Ketorolac for Pain Management
Status:
Completed
Trial end date:
2019-09-10
Target enrollment:
Participant gender:
Summary
The literature regarding analgesic modalities, their combinations and routes of
administrations for patients with pain related to renal colic is expanding. NSAID's (IV
ketorolac) and opioids (morphine) constitutes the mainstay of treatment of renal colic either
alone or in combinations. Despite their synergism and analgesic superiority when administered
together, both classes of these medications possess a set of unfavorable side effects that
limit their use. Emerging data of the use of IV lidocaine for patients with renal colic
demonstrated good analgesic efficacy and safety profile. However, none of the trials directly
compared lidocaine to ketorolac or the combination of both as viable options in patients
unable to tolerate or to have serious contraindications to opioids. We designed a
double-blinded, randomized, controlled trial to evaluate analgesic efficacy, safety and
feasibility of non-opioid analgesics and their combinations in patients with renal colic. The
hypothesis and proposed study will try to determine if a combination of IV lidocaine and
reduced dose of IV ketorolac is superior to either drug alone and if this non-opioid
analgesic modality is effective for controlling pain of renal colic origin.