Intravenous Lidocaine and Ketorolac for Pain Management

• Status: Completed
• Trial end date: 2019-09-10
• Target enrollment: 0
• Participant gender: All

Summary

The literature regarding analgesic modalities, their combinations and routes of administrations for patients with pain related to renal colic is expanding. NSAID's (IV ketorolac) and opioids (morphine) constitutes the mainstay of treatment of renal colic either alone or in combinations. Despite their synergism and analgesic superiority when administered together, both classes of these medications possess a set of unfavorable side effects that limit their use. Emerging data of the use of IV lidocaine for patients with renal colic demonstrated good analgesic efficacy and safety profile. However, none of the trials directly compared lidocaine to ketorolac or the combination of both as viable options in patients unable to tolerate or to have serious contraindications to opioids. We designed a double-blinded, randomized, controlled trial to evaluate analgesic efficacy, safety and feasibility of non-opioid analgesics and their combinations in patients with renal colic. The hypothesis and proposed study will try to determine if a combination of IV lidocaine and reduced dose of IV ketorolac is superior to either drug alone and if this non-opioid analgesic modality is effective for controlling pain of renal colic origin.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Antonios Likourezos
• Treatments: Ketorolac; Ketorolac Tromethamine; Lidocaine

Criteria

Inclusion Criteria:

• Emergency Medicine Patient

• clinical diagnosis of acute renal colic

• pain score of >=5 out of 10 on the numeric rating scale

• - age 18 - 64 years of age

Exclusion Criteria:

• documented or suspected pregnancy, breastfeeding

• contraindication to nonsteroidal anti-inflammatory drugs or lidocaine

• known renal dysfunction

• received analgesics within 4 hours before presentation

• history of bleeding diathesis

• history of peptic ulcer disease

• current use of warfarin

• HR<50 or >150

• history of cardiac arrhythmias

• peritonitis or presence of any peritoneal sign

• altered mental status

• weight > 100kg