Intravenous Heparin as an Adjunct for the Treatment of Anaphylactic Reactions in an Emergency Department

• Status: Withdrawn
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine if intravenous unfractionated heparin (with standard therapy) for treatment of anaphylaxis results in faster time to recovery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Truman Medical Center; University of Missouri, Kansas City
• Collaborators: American College of Emergency Physicians; Emergency Physicians Foundation of KC; Saint Luke's Hospital; Truman Medical Center; University of Missouri, Kansas City
• Treatments: Calcium heparin; Diphenhydramine; Heparin

Criteria

Inclusion Criteria:

• 18 years and older

• English speaking

• Meets one of the above definitions of anaphylaxis

• Signs/symptoms onset <12 hours will get epinephrine or will not get epinephrine because of contraindication to epinephrine administration.

Exclusion Criteria:

• History of Intracranial Hemorrhage at anytime

• Known Cerebral Vascular Lesion (i.e. Aneurysm, Arteriovenous malformation)

• Ischemic CVA within the last 3 months

• Suspected Aortic Dissection

• Active Bleeding

• Known Bleeding/Clotting Disorder

• Closed Head Trauma within the past 3 months

• Major Surgery (Abdominal/Thoracic) within the last 3 weeks

• Active GI Bleeding

• Currently taking Warfarin

• Allergy to Heparins

• History of Heparin-induced Thrombocytopenia (AHA contraindications to fibrinolytic therapy 2005, Micromedix 2007)