Intravenous Dexamethasone and Dexmedetomidine on the Analgesic Efficacy of Erector Spinae Plane Block
Status:
Recruiting
Trial end date:
2021-08-22
Target enrollment:
Participant gender:
Summary
Patients having lumbar spinal fusion often complain about severe postoperative pain and
postoperative rehabilitation process can be affected negatively. Postoperative pain that
cannot be well controlled may lead to delayed mobilization, pulmonary and thromboembolic
complications, prolonged hospital stays, and chronic pain syndromes. Pain after spinal
surgery can arise from several different tissues, such as the vertebrae, disks, ligaments,
dura, facet joint, muscle, fascia, and subcutaneous and cutaneous tissues.
Ultrasound-guided lumbar erector spinae plane block (ESPB) has been shown to reduce
postoperative pain in patients undergoing posterior lumbar interbody fusion (PLIF). However,
the duration of analgesia after single-shot ESPB with commonly used local anesthetics is
reported to be no more than 12 h, which often not long enough to provide satisfactory
postoperative pain relief, as the pain typically lasts for several days. Compared with
perineural route, intravenous additives to local anesthetics are commonly accepted as its
safety and efficiency have been reported. Moreover, co-administration of intravenous
dexamethasone and dexmedetomidine significantly prolonged the time to first rescue analgesic
request after single-shot interscalene brachial plexus block. However, more data are needed
especially for lumbar ESPB.