Overview

Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism

Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
0
Participant gender:
All
Summary
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism. This study may lead to an enhanced understanding of the underlying neurobiological mechanism in high risk individuals that may lead to the transition from moderate to excessive use of alcohol.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Yale University
Collaborators:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
VA Connecticut Healthcare System
Treatments:
Ethanol
Criteria
Inclusion Criteria:

1. Male and female between the ages of 21 and 30 years;

2. medically and neurologically healthy on the basis of history, physical examination,
EKG, Screening laboratories absence of current and/or past substance abuse on the
basis of history and urine toxicology and breath alcohol levels at screening and on
each test day.

For Family History Positive (FHP) Subjects: 1) Biological father and another first or
second-degree biological relative with history of alcoholism by Family History Assessment
Module (FHAM) developed by COGA.

Exclusion Criteria:

1. DSM-IV psychiatric and substance abuse (excluding alcohol abuse) diagnosis by history
on psychiatric evaluation that includes a structured diagnostic interview (Structured
Clinical Interview for Diagnostic and Statistical Manual (DSM)-IV Axis I Disorders
(SCID))

2. Subjects who meet criteria for alcohol abuse and express an interest in stopping
alcohol use and/or express an interest in treatment or are currently enrolled in
treatment for alcoholism, or have sought treatment in the last 6 months.

3. history of counseling or psychotherapy; except family therapy centered around another
family member

4. extended unwillingness to remain alcohol-free for 48 hours prior to test days;

5. for women: positive pregnancy test at screening or intention to engage in unprotected
sex during the study

6. alcohol naïve

7. Adoptee and no contact with family members.