Overview

Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department

Status:
Recruiting
Trial end date:
2022-06-03
Target enrollment:
0
Participant gender:
All
Summary
In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine. However, the data are sparse to support this strategy. Thus, the purpose of our research is to test non-inferiority of IV morphine alone versus IV acetaminophen and morphine in a multicenter, randomized, controlled double blind trial in ED patients with moderate to severe acute pain.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Nantes University Hospital
Treatments:
Acetaminophen
Morphine
Criteria
Inclusion Criteria:

- 18 Years and older

- Moderate to severe acute pain, defined as a numeric rating scale score greater than or
equal to 5.

- Conscious patient

- Clinical stability at the physician's discretion

- Patient able to talk and give a verbal assessment of his/her pain with the numerical
verbal scale

- Out of guardianship and/or tutorship

- Affiliated to the social security plan.

Exclusion Criteria:

- Pregnancy and Breast-feeding

- Patient Unable to give numeric rating scale scores

- Patient with a weight strictly less than 50kg.

- acute pulmonary edema, acute respiratory failure

- Acute coronary syndrome or unbalanced ischemic heart disease in progress.

- Acute alcoholic intoxication.

- Patient who received morphine, or acetaminophen, or analgesic, or anti-inflammatory,
for the current acute pain episode, within 8 hours prior to arrival at the emergencies

- No possibility of having venous access

- History of chronic pain during treatment.

- Allergy, intolerance or know contraindication to paracetamol or morphine or to an
excipient.

- Renal or hepatic insufficiency.

- Association with buprenorphine, nalbuphine and pentazocine.

- Patient unable or unable to give written consent.