Intrauterine Infusion of GCSF and Reproductive Outcomes in Infertile Women With History of RIF

• Status: Recruiting
• Trial end date: 2022-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

Intrauterine infusion of granulocyte colony stimulating factor and reproductive outcomes in infertile women with history of recurrent implantation failure: a randomized controlled trial

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cairo University
• Treatments: Lenograstim; Sargramostim

Criteria

Inclusion Criteria:

1. Age group (18-38)

2. History of at least 2 previous IVF or ICSI trial failures with ET of at least 2 good quality embryos in each trial.

3. Endometrial cavity within normal anatomy as assessed with transvaginal ultrasound (TV-US) with or without hysteroscopy and HSG if needed.

4. Availability of good quality embryos (at least 2 grade A embryos) for ET in the investigated trial

Exclusion Criteria:

Any factor which may affect quality of embryos transferred or endometrial receptivity and embryo growth, like:

1. Severe male factor infertility

2. Poor ovarian reserve (according to ESHRE criteria) 1

3. Uterine anatomic factor (eg polyp, intramural fibroid, endometrial septum, intrauterine synechiae .. etc) as well as endometritis

4. Immunological disorder (eg: SLE, APS, … etc)

5. Thyroid or adrenal dysfunction

6. Thrombophilia history or tendency as proven by labs in suspected women

7. Untreated hyperprolactinemia

8. Genetic abnormalities in the infertile couple

9. Chronic hematologic, renal or liver disease