Intrathecal Opioids for Colorectal Resection

• Status: Recruiting
• Trial end date: 2022-01-15
• Target enrollment: 0
• Participant gender: All

Summary

This research study is being done to determine the optimal dose of spinal morphine and hydromorphone in patients undergoing minimally-invasive (i.e., surgery performed through small entry sites and using cameras) colorectal surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mayo Clinic
• Treatments: Hydromorphone; Morphine

Criteria

Inclusion Criteria:

• Adult patients with an American Society of Anesthesiologists (ASA) physiological status I-III.

• Undergoing colorectal minimally invasive surgery (MIS).

• Age between 18 and 75 years of age.

• Body mass index (BMI) between 18.5 and 40.

• Ability to understand and read English.

Exclusion Criteria:

• Not able or unwilling to sign consent.

• Patients undergoing ileostomy closure.

• Patients undergoing ambulatory surgery or anticipated to be discharged sooner than 24 hours after surgery

• Patients with chronic pain, requiring daily opioid use at the time of surgery.

• Patient intolerant or allergic to opioids, NSAIDs, or acetaminophen.

• Patients requiring emergent surgery.

• Any contraindication to neuraxial anesthesia (coagulopathy, localized infection at the site of injection, pre-existing spinal pathology, or peripheral neuropathy).

• Any patients currently receiving any anticoagulation medication other than aspirin and who have not discontinued the medication per American Society of Regional Anesthesia anticoagulation guidelines22, and/or an abnormal INR.

• Patients with hepatic or renal insufficiency in as much as the patient is not a candidate for acetaminophen or NSAIDs, respectively.