Intrathecal Dexmedetomidine With Bupivacaine for Spinal Anesthesia in Cesarean Section

• Status: Completed
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

A Randomized, Controlled, Double blind study aiming to evaluate the analgesic potentials and side effect profile of different dose levels of Dexmedetomidine added to subarachnoid bupivacaine in full-term pregnant women undergoing elective cesarean section using spinal anesthesia. The investigators ultimate goal is to find out the least effective dose which will be associated with minimal or no side effects. The primary outcome will be the time to two sensory block segment regression.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Anesthetics; Bupivacaine; Dexmedetomidine

Criteria

Inclusion Criteria:

• Full-term pregnant women.

• Elective cesarean section using spinal anesthesia.

• Singleton gestation.

• American Society of Anesthesiologists (ASA) physical status classes I and II.

Exclusion Criteria:

• Preterm pregnancy (<37 wks gestation).

• Multiple gestation.

• Cardiovascular disease (e.g., preeclampsia, hypertension) and the use of antihypertensive medication.

• Conditions that preclude spinal anesthesia.

• Failed spinal block and conversion to general anesthesia.

• A history of established chronic pain.

• Drug addiction.

• A psychiatric disorder.

• Inability to communicate effectively.

• Asthma and allergy to non-steroidal anti-inflammatory drugs.