Intrathecal Dexamethasone and Atropine on Morphine Induced Post-operative Nausea and Vomiting on Caesarean Section

• Status: Not yet recruiting
• Trial end date: 2025-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

Pain is a major problem during the postoperative period and can be considered as a challenge for the anesthesiologist. Low dose intrathecal morphine is proven efficient as a mode to reduce postoperative pain. Morphine has many complications like post-operative nausea and vomiting (PONV). we will investigate the utility of intrathecal (IT) atropine and dexamethasone for prevention of morphine induced PONV as a primary outcome in parturient undergoing CS under spinal bupivacaine anesthesia plus morphine sulfate as an adjuvant.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Atropine; Dexamethasone

Criteria

Inclusion Criteria:

1. Female

2. 18-45 years old

3. ASA: 1, 2

4. Elective caesarean section under spinal anaesthesia.

Exclusion Criteria:

1. Patient refusal.

2. Contraindications to spinal anaesthesia as coagulopathy, infection at site of injection, hemodynamic instability and uncooperative patient.

3. Contraindications to administration of morphine as asthmatic patient and hypersensitivity and contraindications to any of the study drugs.

4. Adult-Emergency CS as there is no time for preparation and risk on fetus and mother for time consuming