Overview

Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis

Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
0
Participant gender:
All
Summary
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP), intra-articular injection of PRP and a single application of hyaluronic acid (HA).
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Cangzhou Central Hospital
Treatments:
Hyaluronic Acid
Criteria
Inclusion Criteria:

- Unilateral symptomatic knee with pain for at least 1 month or swelling.

- Radiographic findings of knee degeneration (Kellgren-Lawrence score of II - III).

- Age 40-73 years.

- Body mass index (BMI) 18-32.5).

- Knee stability without a severe trauma history.

Exclusion Criteria:

- Bilateral knee osteoarthritis indicative of treatment for both knees.

- Kellgren-Lawrence score greater than III.

- BMI >32.

- Age >73 years.

- Systemic autoimmune rheumatic diseases and blood disorders.

- Active immunosuppressive or anticoagulant therapy.

- Intra-articular injection to the knee within the previous 1 year or previous joint
infection.

- use of corticosteroids for 3 weeks before the procedure.

- use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the 3 weeks before treatment.