Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery
Status:
Recruiting
Trial end date:
2022-04-30
Target enrollment:
Participant gender:
Summary
Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of
pain or increased sensitivity to non-painful stimuli at the site of surgery or at a
surrounding area that was not directly injured. Opioid-induced hyperalgesia (OIH) and
nociceptive-induced hyperalgesia (NIH) are the two main causes of POH.N-methyl-D-aspartate
receptor (NMDAR) activation plays a central role in the development of POH.S-ketamine，which
is a NMDA-receptor antagonist,has been on the market in china since 2019.The aim of this
study is to evaluate the effects of S-ketamine on POH and chronic postoperative pain after
video-assisted thoracic surgery.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University