Intraoperative S-ketamine to Prevent Postoperative Hyperalgesia in Patients Undergoing Video-assisted Thoracic Surgery

• Status: Recruiting
• Trial end date: 2022-04-30
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative hyperalgesia (POH) is a paradoxical clinical state of increased sensation of pain or increased sensitivity to non-painful stimuli at the site of surgery or at a surrounding area that was not directly injured. Opioid-induced hyperalgesia (OIH) and nociceptive-induced hyperalgesia (NIH) are the two main causes of POH.N-methyl-D-aspartate receptor (NMDAR) activation plays a central role in the development of POH.S-ketamine，which is a NMDA-receptor antagonist,has been on the market in china since 2019.The aim of this study is to evaluate the effects of S-ketamine on POH and chronic postoperative pain after video-assisted thoracic surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Treatments: Esketamine; Ketamine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) physical status class I-III.

• elective single-port video-assisted thoracic surgery under general

Exclusion Criteria:

• a history of thoracic surgery

• a history of chronic pain

• ongoing pain treatment

• opioid drug or alcohol abuse

• a history of allergy to anesthetics

• obesity (body mass index [BMI] >30 kg/m2 )

• pregnancy

• psychiatric disorders

• neurological disease

• severe diabetes

• renal or hepatic insufficiency

• uncontrolled hypertension, or arrhythmia