Intraoperative Nasal Insulin Effect on Plasma and CSF Insulin Concentration and Blood Glucose
Status:
Recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
Intranasal insulin is reported to improves memory performance in patients suffering from
cognitive impairment. The investigators have previously shown that intraoperative insulin
administration preserves both short and long-term memory function after cardiac surgery.
Applying intranasal insulin bypasses blood-brain barrier and cause elevation of insulin
concentrations in the cerebrospinal fluid without major effects on peripheral insulin level.
Patients undergoing major surgery are exposed to carbohydrate and insulin metabolism
alteration. The goal of the study is to study the effect of intranasal insulin on blood
glucose, plasma and cerebrospinal insulin concentration in patients undergoing cardiac
surgery or endovascular thoracic aneurysm repair.