Intraoperative NOL Titration

• Status: Recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Cleveland Clinic
• Treatments: Analgesics, Opioid; Fentanyl

Criteria

Inclusion Criteria:

• Adults having major non-cardiac surgery expected to last ≥2 hours

• American Society of Anesthesiologists physical status 1-3

• Age 21-85 years old

• Planned endotracheal intubation

Exclusion Criteria:

• Planned neuraxial or regional block

• Clinician preference for an opioid other than, or in addition to, fentanyl

• Non-sinus heart

• Neurologic condition that, in the opinion of the investigators, may preclude accurate assessment of postoperative pain and nausea

• Lack of English language fluency

• Routine user of psychoactive drugs other than opioids

• Contraindication to sevoflurane, fentanyl, morphine, or ondansetron.

• Intracranial surgery.

• BMI > 40