Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients

• Status: Unknown status
• Trial end date: 2020-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether a low-dose ketamine infusion can be used as the main intra-operative analgesic in different burn patients, and thereby reduce the total intra-operative opioid requirement. Secondary objectives are to determine whether this low-dose ketamine infusion will lengthen the amount of time to the first narcotic given in the recovery room or ICU, and whether pain scores for awake patients will be lower post-operatively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Loyola University
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• All adult burn patients aged 18-80 presenting to the operating room, both intubated and non-intubated

• Patients having a procedure performed in Russo operating rooms at Loyola University Medical Center

Exclusion Criteria:

• Allergy to ketamine or benzodiazepines

• Ketamine use in the preceding 24 hours

• Children (patients under age 18), prisoners, pregnant or breastfeeding women, patients with psychosis, patients with developmental delay, and any condition which, in the opinion of the investigator, would prevent full participation in this study or would interfere with the evaluation of the trial endpoints.

• Increased intracranial pressure at the discretion of the investigator

• Increased intraocular pressure at the discretion of the investigator

• Porphyria at the discretion of the investigator

• Thyroid disorders at the discretion of the investigator