Intraoperative Lidocaine and Combined With Ketamine on Opioid After Bariatric Surgery

• Status: Not yet recruiting
• Trial end date: 2022-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The most effective long-term treatment for obesity is bariatric surgery, however, postoperative pain control is challenging in these group of population. Opioid-sparing technique with multimodal analgesia is recommended but the evidence supported is still limited. Multimodal analgesia, particularly lidocaine and ketamine, has been used effectively in various type of surgery. However, the evidence supported their use in obese patients undergoing bariatric surgery is limited.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mahidol University
• Treatments: Ketamine; Lidocaine

Criteria

Inclusion Criteria:

1. Adults patients age older than 18 years.

2. Body mass index more than 30 kg/m2.

3. Scheduled for laparoscopic bariatric surgery, including laparoscopic sleeve gastrectomy, robotic-assisted laparoscopic sleeve gastrectomy, laparoscopic Roux-en-Y gastric bypass surgery or robotic-assisted laparoscopic gastric bypass.

Exclusion Criteria:

1. Patient refusal.

2. Inability to communicate or read in Thai language.

3. Allergic to lidocaine or ketamine.

4. History of opioid use within 2 weeks before surgery

5. Cardiovascular disorder, including high grade atrioventricular block (second degree or third degree), history of coronary artery disease, poor controlled hypertension.

6. History of stroke, intracranial hemorrhage or intracranial mass

7. Cognitive impairment

8. Schizophrenia or history of antipsychotic drugs

9. Pregnant or breast-feeding patients

10. Conversion to open surgery