Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty

• Status: Recruiting
• Trial end date: 2021-09-30
• Target enrollment: 0
• Participant gender: All

Summary

Prospective randomized double blinded, placebo controlled study that will evaluate the effect of intra-operative ketamine administration on post-operative analgesic requirements and self-reported pain in patients undergoing total hip and total knee arthroplasty who demonstrate high levels of pain catastrophizing.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dartmouth-Hitchcock Medical Center
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Adults, 18 years and older, undergoing primary total hip arthroplasty or total knee arthroplasty

Exclusion Criteria:

• History of intolerance or allergy to ketamine, either documented or self-reported.

• History of increased intra-ocular pressure, uncontrolled hypertension, increased intra-cranial pressure, psychosis.

• Unable to provide consent.

• Current incarceration.

• Pregnant or breast feeding