Intraoperative Goal-directed Blood Pressure and Dexmedetomidine
Status:
Active, not recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
Perioperative organ injuriy remain an important threat to patients undergoing major
surgeries. Intraoperative hypotension is associated with an increase in postoperative
morbidity and mortality. Whereas individualized intraoperative blood pressure management is
likely to decrease the incidence of postoperative organ injury when compared with standard
blood pressure management strategy. Dexmedetomidine, a highly selective alpha2 adrenergic
agonist, has been shown to provide organ protective effects. This study aims to investigate
the impact of intraoperative goal-directed blood pressure management and dexmedetomidine
infusion on incidence of postoperative organ injury in high-risk patients undergoing major
surgery.