Intraoperative EEG Monitoring and Postoperative Delirium in Elderly Patients With Sevoflurane Anesthesia

• Status: Recruiting
• Trial end date: 2022-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Delirium is an acute onset of attentional and cognitive impairment. BIS guided anesthesia can reduce the incidence of postoperative delirium. Long term electroencephalogram (EEG) suppression during operation is related to postoperative delirium. The latest research shows that the anesthesia depth guided by EEG does not reduce the incidence of postoperative delirium. The purpose of this study was to explore the relationship between anesthesia exposure with different minimum alveolar concentration(MAC) and postoperative delirium(POD), and to observe the characteristics of EEG.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The First Affiliated Hospital of Anhui Medical University
• Treatments: Anesthetics; Benzocaine; Sevoflurane

Criteria

Inclusion Criteria:

• Clinical diagnosis of gastrointestinal diseases

• Patients were aged 60 to 90 years

• American Society of Anesthesiologists (ASA) risk classification II-IV

• Patients were scheduled to undergo elective major abdominal operation(with a anticipated time of 2-6 h)

Exclusion Criteria:

• Preoperative dementia or cognitive impairment

• Mental instability or mental illness

• Patients with any factors affecting cognitive assessment, such as language, vision and hearing impairment

• Any cerebrovascular accident occurred within 3 months, such as stroke etc

• Previous history of delirium

• Known hypersensitivity to sevoflurane or history of malignant hyperthermia

• Abuse of narcotic sedative and analgesic drugs

• Those who have reoperation within 7 days after operation