Intraoperative Dexmedetomidine and Long-term Outcomes in Elderly After Major Surgery

• Status: Active, not recruiting
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a 3-year follow-up of patients enrolled in a previous randomized controlled trial which showed that intraoperative dexmedetomidine reduced delirium in elderly patients after major non-cardiac surgery. The purpose of this study is to clarify the effects of intraoperative dexmedetomidine on long-term outcomes of these patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Elderly patients (age ≥60 years);

• Scheduled to undergo elective major non-cardiac surgery with expected duration ≥2 hours under general anaesthesia.

Exclusion Criteria:

• Do not provide written informed consent;

• Previous history of schizophrenia, epilepsy or Parkinson's disease;

• Visual, hearing, language or other barriers which impede communication and preoperative delirium assessment;

• History of traumatic brain injury;

• Severe bradycardia (heart rate <40 beats per minutes), sick sinus syndrome, or atrioventricular block of degree 2 or above without pacemaker;

• Severe hepatic dysfunction (Child-Pugh grade C);

• Renal failure (requirement of renal replacement therapy);

• Neurosurgery.