Intranasal Ketamine Versus Subcutaneous Ketamine for Treatment of Acute Pain in the Emergency Department ( INVESCK )

• Status: Not yet recruiting
• Trial end date: 2025-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Pain is the most common complaint for emergency department (ED) visit. Intranasal ketamine has been shown to provide rapid, well-tolerated, effective analgesia to emergency department (ED) patients with acute pain. few trials have studied ketamine infusion subcutaneously for pain management in trauma patients.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Monastir
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• • Patients who presented to the ED with acute limb trauma pain with a visual analgesic scale (VAS) of 5 or more on a standard 11 point (0-10).

• Pain was considered traumatic if it is reported as appearing immediately after the trauma and no anterior pain was described in the same limb.

Exclusion Criteria:

• Pregnancy/Breastfeeding

• altered mental status (GCS<15)

• Allergy to ketamine or morphine

• Weight less than 40 kg or greater than 100kg

• Unstable vital signs (systolic blood pressure <90 or > 180mmHg, pulse rate<50 or >150bpm, and respiration rate <10 or >30 breath/min)

• Medical history of acute head or eye injury

• Medical history of seizure

• Medical history of intracranial hypertension,

• Medical history of chronic pain,

• Medical history of severe renal or hepatic insufficiency.

• Medical history of glaucoma

• Alcohol or drug abuse

• Psychiatric illness,

• Recent (4 hours before) analgesic agent use.