Intranasal Insulin for Treatment of Alcohol Use Disorder
Status:
Recruiting
Trial end date:
2025-03-30
Target enrollment:
Participant gender:
Summary
This is a randomized controlled trial (RCT), within-subject, crossover, double-blind,
placebo-controlled in non-treatment-seeking individuals with Alcohol Use Disorder (AUD)
(N=40, 50% female) randomized to IN insulin or placebo. In a bar laboratory setting,
randomized participants will receive a single dose of IN insulin (80IU) or an IN matched
placebo (0.9% Saline). Participants will undergo a cue-reactivity paradigm followed by an
alcohol challenge that includes an alcohol drink designed to raise the breath alcohol content
(BrAC) to 0.08g/dL.