Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients
Status:
Recruiting
Trial end date:
2023-08-31
Target enrollment:
Participant gender:
Summary
Postoperative neurocognitive disorders (PND) are common postoperative complication of central
nervous system, leading to increased risk of the working ability loss after surgery, longer
hospital stay, increased medical costs and increased surgical mortality. It is classified as
perioperative neurocognitive disorders in mental disorders.Aging is an important demographic
characteristic in China, and the elderly is also a population susceptible to PND. There is a
lack of targeted prevention and control measures for PND. Central insulin resistance is an
important mechanism of cognitive impairment in elderly patients, and exogenous supply of
central insulin may be an important measure to improve PND. Compared with conventional
subcutaneous and intravenous supply, intranasal insulin administration not only has little
effect on blood glucose and insulin levels, but also enters the center through the
blood-brain barrier easily and efficiently. Long-term use of intranasal insulin can improve
the cognitive function of chronic diseases, but there is a lack of clinical studies on
improving PND by intranasal insulin. This study will verify the effectiveness of intranasal
insulin in the PND improvement of elderly patients.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Collaborators:
521 Hospital of NORINCO Group LanZhou University Second Hospital of Shanxi Medical University Sichuan Provincial People's Hospital Tang-Du Hospital The First Affiliated Hospital of Zhengzhou University Tongji Hospital